The museum was opened on February 21, 1981, in a former manor house rebuilt during the Soviet era. The museum exposition shared information about the rich historical heritage of Boryspil region and, in particular, the town of Ivankiv, from the Stone Age to the present, covered the Bronze Age, Scythian period, Kyivan Rus, Cossacks, the Ukrainian revolution of 1917-1921, collectivization, The Holodomor, the pre-war period and the period of the World War II. The museum organized thematic meetings, exhibitions and scientific conferences.

The most valuable part of the collection was a collection of works by world-famous Ukrainian artist Mariia Prymachenko. An original Ukrainian folk artist created over 800 paintings in the style of naïve art. In the World Encyclopedia of Naïve Art, she is recognized as a high-profile celebrity, along with Henri Rousseau, Henri Matisse, and Niko Pirosmani. Marc Chagall admired her work, and Pablo Picasso recognized her as a genius. In honour of the 100th anniversary of the artist’s birth, 2009 was declared by UNESCO the Year of Mariia Prymachenko.

On February 27th, 2022, the Russian occupiers destroyed the museum, which housed more than 400 exhibits. Some of Prymachenko’s paintings from the museum’s collection were in a temporary exhibition in Kyiv, some were saved from the burning building by locals, thanks to which these works escaped destruction. The fate of the rest of the exhibits is unknown. As a result of the shelling, the museum building burned down completely.